What does the acronym SLUDGE stand for in toxicology?

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Multiple Choice

What does the acronym SLUDGE stand for in toxicology?

Explanation:
In toxicology, SLUDGE is a mnemonic for the muscarinic signs of cholinergic excess, such as from acetylcholinesterase inhibitors like organophosphates. It stands for Salivation, Lacrimation, Urination, Defecation, GI distress, and Emesis. These symptoms arise because excess acetylcholine stimulates muscarinic receptors, increasing secretions and gut motility. This helps you recognize a cholinergic crisis and distinguishes it from other toxic patterns, like opioid toxicity (which centers on respiratory depression) or anticholinergic toxicity (which causes dry mucous membranes and other opposite signs).

In toxicology, SLUDGE is a mnemonic for the muscarinic signs of cholinergic excess, such as from acetylcholinesterase inhibitors like organophosphates. It stands for Salivation, Lacrimation, Urination, Defecation, GI distress, and Emesis. These symptoms arise because excess acetylcholine stimulates muscarinic receptors, increasing secretions and gut motility. This helps you recognize a cholinergic crisis and distinguishes it from other toxic patterns, like opioid toxicity (which centers on respiratory depression) or anticholinergic toxicity (which causes dry mucous membranes and other opposite signs).

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